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In liquid pharmaceuticals solutions sometimes the active drug is poorly soluble or insoluble in the desired solvent and could not able to achieve the required concentration of formulation. In such cases, it is required to increase the solubility of that material in the solvent by a suitable technique. Solubilization is the technique by which the desired solubility of a poorly water-soluble substance is achieved.
Since water is the most commonly used solvent in pharmaceutical liquids, the following techniques have been aimed at increasing the solubility of a drug substance in water.
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- Pharmaceutical Approach
- pH Adjustments
- Surface Active Agents
- Solid Solutions
- Chemical Modifications
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