B.Pharm Pharmaceutical Organic Chemistry 3 Notes

PHARMACEUTICAL ORGANIC CHEMISTRY 3 UNIT-WISE NOTES – BP401T

Unit – 1

• Stereo isomerism
• Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
• Elements of symmetry, chiral and achiral molecules
• DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
• Reactions of chiral molecules
• Racemic modification and resolution of racemic mixture.
• Asymmetric synthesis: partial and absolute

Unit – 2

• Geometrical isomerism
• Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
• Methods of determination of configuration of geometrical isomers.
• Conformational isomerism in Ethane, n-Butane and Cyclohexane.
• Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
• Stereospecific and stereoselective reactions

Unit – 3

• Heterocyclic compounds:
• Nomenclature and classification
• Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

Unit – 4

• Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole.
• Basicity of pyridine, Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

Unit – 5

• Reactions of synthetic importance
• Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
• Oppenauer-oxidation and Dakin reaction.
• Beckmanns rearrangement and Schmidt rearrangement.
• Claisen-Schmidt condensation