B.Pharm Novel Drug Delivery System Notes

NOVEL DRUG DELIVERY SYSTEM UNIT-WISE NOTES – BP704T

Unit – 1

• Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles.
• Physicochemical and biological properties of drugs relevant to controlled release formulations
• Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.

Unit – 2

• Microencapsulation: Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications
• Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems
• Implantable Drug Delivery Systems:Introduction, advantages and disadvantages, concept of implantsand osmotic pump

Unit – 3

• Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
• Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS Floating, high density systems, inflatable and gastroadhesive systems and their applications
• Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

Unit – 4

• Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

Unit – 5

• Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts
• Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications