HUMAN ANATOMY, PHYSIOLOGY AND PATHOPHYSIOLOGY 1 UNIT-WISE NOTES – BP104T, B.Pharma 1st Semester
Unit – 1
Introduction to human body
- Cellular and tissue level of organization.
- Definition and scope of anatomy, physiology and pathophysiology.
- Levels of structural organization and body systems, basic life processes, homeostasis, basic anatomical terminologies.
- Structure and functions of cell, transport across cell membrane, cell division, cell junctions. General principles of cell communication, forms of intracellular signalling a) Contact-dependent, b) Paracrine, c) Synaptic, d) Endocrine
- Classification of tissues, structure, location and functions of epithelial, muscular and nervous and connective tissues.
- Basic principles of cell injury and adaptation
- Components and types of feedback systems, causes of cellular injury, pathogenesis (cell membrane damage, mitochondrial damage, ribosome damage and nuclear damage), morphology of cell injury – adaptive changes (atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia), cell swelling, intra cellular accumulation and cell death.
- Definitions of commonly used relevant medical terminologies.
Unit – 2
Integumentary system and wound healing
- Structure and functions of skin. Skin disorders: Psoriasis and dermatitis and pathophysiology of Leprosy. Basic principles of wound healing.
- Skeletal system and joints
- Divisions of skeletal system, types of bones, salient features and functions of bones of axial and appendicular skeletal system.
- Organization of skeletal muscle, physiology of muscle contraction, neuromuscular junction. Structural and functional classification of joints.
- Diseases of bones and joints
- Pathophysiology of rheumatoid arthritis, osteoporosis and gout.
Unit – 3
Body fluids, blood and lymphatic system
- Body fluids, composition and functions of blood, hemopoiesis, formation of haemoglobin, mechanisms of coagulation, blood grouping, Rh factors and transfusion.
- Lymphatic organs and tissues, lymphatic vessels, lymph formation, circulation and functions of lymphatic system.
- Basic mechanism of inflammation and repair: Introduction, classification and pathophysiology of inflammation, mediators of inflammation.
- Haematological diseases: Pathophysiology of iron deficiency, megaloblastic anaemia (Vit B12 and folic acid), sickle cell anaemia, Thalassemia, hereditary acquired anaemia and haemophilia.
Unit – 4
Peripheral nervous system
- Classification of peripheral nervous system: structure and functions of sympathetic and parasympathetic nervous system. Origin and functions of spinal and cranial nerves.
- Special senses: Structure and functions of eye, ear, nose and tongue. Pathophysiology of special sense disorders- glaucoma, cataract, myopia, otitis externa, otitis media, vertigo and anosmia
Unit – 5
Cardiovascular system
- Anatomy of heart, blood circulation, blood vessels, structure and functions of artery, vein and capillaries, elements of conduction system of heart and heartbeat, its regulation by autonomic nervous system,
- cardiac output, cardiac cycle. Regulation of blood pressure, pulse, electrocardiogram.
- Pathophysiology of hypertension, cardiac arrhythmias, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and coronary artery disease).