B.Pharm Biostatistics and Research Methodology Notes

BIOSTATISTICS AND RESEARCH METHODOLOGY UNIT-WISE NOTES – BP801ET

Unit – 1

  • Introduction: Statistics, Biostatistics, Frequency distribution, Measures of central tendency: Mean, Median, Mode- Pharmaceutical examples
  • Measures of dispersion: Dispersion, Range, standard deviation, Pharmaceutical problems
  • Correlation: Definition, Karl Pearson’s coefficient of correlation, Multiple correlation- Pharmaceuticals examples

Unit – 2

  • Regression: Curve fitting by the method of least squares, fitting the lines y= a + bx and x = a + by, Multiple regression, standard error of regression– Pharmaceutical Examples
  • Probability: Definition of probability, Binomial distribution, Normal distribution, Poisson’s distribution, properties – problems Sample, Population, large sample, small sample, Null hypothesis, alternative hypothesis, sampling, essence of sampling, types of sampling, Error-I type, Error-II type, Standard error of mean (SEM) – Pharmaceutical examples
  • Parametric test: t-test(Sample, Pooled or Unpaired and Paired) , ANOVA, (One way and Two way), Least Significance difference

Unit – 3

  • Non Parametric tests: Wilcoxon Rank Sum Test, Mann-Whitney U test, Kruskal-Wallis test, Friedman Test
  • 156Introduction to Research: Need for research, Need for design of Experiments, Experiential Design Technique, plagiarism Graphs: Histogram, Pie Chart, Cubic Graph, response surface plot, Counter Plot graph
  • Designing the methodology: Sample size determination and Power of a study, Report writing and presentation of data, Protocol, Cohorts studies, Observational studies, Experimental studies, Designing clinical trial, various phases.

Unit – 4

  • Blocking and confounding system for Two-level factorials
  • Regression modeling: Hypothesis testing in Simple and Multiple regressionmodels
  • Introduction to Practical components of Industrial and Clinical Trials Problems: Statistical Analysis Using Excel, SPSS, MINITAB®, DESIGN OF EXPERIMENTS, R – Online Statistical Software’s to Industrial and Clinical trial approach

Unit – 5

  • Design and Analysis of experiments:
  • Factorial Design: Definition, 22, 23design. Advantage of factorial design
  • Response Surface methodology: Central composite design, Historical design, Optimization Techniques

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