Medicinal Chemistry 3 B.Pharm 6th Semester Books

Medicinal Chemistry III Book for B.Pharm 6th Semester

Author’s Name	Dr. (Prof.) V.N. Indulatha Dr. Rakesh Kumar Dr. Neha Tiwari
Editions	Latest Edition
Publishers	Thakur Publication Pvt Ltd

TEXTBOOK OF MEDICINAL CHEMISTRY-III (B.PHARM) SEMESTER-VI

Author’s Name	VARUN AND DAVINDER PRAGI
Editions	Latest Edition
Publishers	S VIKAS AND COMPANY (PV)

Text Book of Medicinal Chemistry-III for the Students of B.Pharm 6th Semester

Author’s Name	Dr. Durga Prasad Kemisetti
Editions	First Edition
Publishers	IP Innovative Publication Pvt. Ltd.

Medicinal Chemistry 3 Topic-wise Summary

Antibiotics

1. Historical background
   
2. Nomenclature
   
3. Stereochemistry
   
4. Structure–Activity Relationship (SAR)
   
5. Chemical degradation, classification, and important products of the following classes:
   
   • β-Lactam antibiotics
     
     • Penicillin
       
     • Cephalosporins
       
     • β-Lactamase inhibitors
       
     • Monobactams
       
   • Aminoglycosides
     
     • Streptomycin
       
     • Neomycin
       
     • Kanamycin
       
   • Tetracyclines
     
     • Tetracycline
       
     • Oxytetracycline
       
     • Chlortetracycline
       
     • Minocycline
       
     • Doxycycline

Antibiotics

1. Historical background
   
2. Nomenclature
   
3. Stereochemistry
   
4. Structure–Activity Relationship (SAR)
   
5. Chemical degradation, classification, and important products of the following classes:
   
   • Macrolides
     
     • Erythromycin
       
     • Clarithromycin
       
     • Azithromycin
       
   • Miscellaneous
     
     • Chloramphenicol*
       
     • Clindamycin
       
6. Prodrugs
   
   • Basic concepts
     
   • Applications in prodrug design
     

Antimalarials

1. Etiology of malaria
   
2. Quinolines (SAR and examples):
   
   • Quinine sulphate
     
   • Chloroquine*
     
   • Amodiaquine
     
   • Primaquine phosphate
     
   • Pamaquine*
     
   • Quinacrine hydrochloride
     
   • Mefloquine
     
3. Biguanides and dihydrotriazines:
   
   • Cycloguanil pamoate
     
   • Proguanil
     
4. Miscellaneous:
   
   • Pyrimethamine
     
   • Artesunate
     
   • Artemether
     
   • Atovaquone

Anti-tubercular Agents

1. Synthetic anti-tubercular agents
   
   • Isoniazid*
     
   • Ethionamide
     
   • Ethambutol
     
   • Pyrazinamide
     
   • Para-amino salicylic acid*
     
2. Anti-tubercular antibiotics
   
   • Rifampicin
     
   • Rifabutin
     
   • Cycloserine
     
   • Streptomycin
     
   • Capreomycin sulphate
     

Urinary Tract Anti-Infective Agents

1. Quinolones (SAR and examples):
   
   • Nalidixic acid
     
   • Norfloxacin
     
   • Enoxacin
     
   • Ciprofloxacin*
     
   • Ofloxacin
     
   • Lomefloxacin
     
   • Sparfloxacin
     
   • Gatifloxacin
     
   • Moxifloxacin
     
2. Miscellaneous:
   
   • Furazolidine
     
   • Nitrofurantoin*
     
   • Methenamine
     

Antiviral Agents

• Amantadine hydrochloride
  
• Rimantadine hydrochloride
  
• Idoxuridine trifluoride
  
• Acyclovir*
  
• Ganciclovir
  
• Zidovudine
  
• Didanosine
  
• Zalcitabine
  
• Lamivudine
  
• Loviride
  
• Delavirdine
  
• Ribavirin
  
• Saquinavir
  
• Indinavir
  
• Ritonavir

Antifungal Agents

1. Antifungal antibiotics
   
   • Amphotericin-B
     
   • Nystatin
     
   • Natamycin
     
   • Griseofulvin
     
2. Synthetic antifungal agents
   
   • Clotrimazole
     
   • Econazole
     
   • Butoconazole
     
   • Oxiconazole
     
   • Tioconazole
     
   • Miconazole*
     
   • Ketoconazole
     
   • Terconazole
     
   • Itraconazole
     
   • Fluconazole
     
   • Naftifine hydrochloride
     
   • Tolnaftate*
     

Anti-protozoal Agents

• Metronidazole*
  
• Tinidazole
  
• Ornidazole
  
• Diloxanide
  
• Iodoquinol
  
• Pentamidine isethionate
  
• Atovaquone
  
• Eflornithine
  

Anthelmintics

• Diethylcarbamazine citrate*
  
• Thiabendazole
  
• Mebendazole*
  
• Albendazole
  
• Niclosamide
  
• Oxamniquine
  
• Praziquantel
  
• Ivermectin
  

Sulphonamides and Sulfones

1. Sulphonamides
   
   • Historical development
     
   • Chemistry
     
   • Classification
     
   • SAR
     
   • Examples:
     
     • Sulphamethizole
       
     • Sulfisoxazole
       
     • Sulphamethizine
       
     • Sulfacetamide*
       
     • Sulphapyridine
       
     • Sulfamethoxazole*
       
     • Sulphadiazine
       
     • Mefenide acetate
       
     • Sulfasalazine
       
2. Folate reductase inhibitors
   
   • Trimethoprim*
     
   • Cotrimoxazole
     
3. Sulfones
   
   • Dapsone*

Introduction to Drug Design

1. Various approaches used in drug design
   
2. Physicochemical parameters in QSAR (Quantitative Structure–Activity Relationship):
   
   • Partition coefficient
     
   • Hammett’s electronic parameter
     
   • Taft’s steric parameter
     
   • Hansch analysis
     
3. Pharmacophore modeling and docking techniques
   
4. Combinatorial chemistry
   
   • Concept and applications
     
   • Solid phase synthesis
     
   • Solution phase synthesis