Physical Pharmaceutics 1 Important Questions are most helpful for the B.Pharm 3rd semester examination. You can also download the suggestions PDF.
Solubility of Drugs
Very Short Answer Questions
1. Define solubility and solution.
2. What is mole fraction?
3. Give the different liquid-liquid systems.
4. What are binary solutions? Give some examples.
5. Give examples of ideal and non-ideal solutions.
6. Draw a phase solubility diagram of any one partially miscible liquid.
7. State Fick’s first law of diffusion.
8. Give the Higuchi equation.
Short Answer Questions
1. Write a note on polar solvents.
2. Discuss how pressure and temperature affect drug solubility.
3. Explain Raoult’s law and its deviations.
4. Discuss azeotropic mixtures.
5. Write a short note on steady state diffusion.
6. Give the pH-partition hypothesis.
7. Discuss uterine diffusion.
Long Answer Type Question
1. Discuss the mechanisms of solute-solvent interactions.
2. Write a note on fractional distillation.
3. Explain critical solution temperature and its applications.
4. Give a brief review of the role of non-ideal solutions in the solubility of solids in liquids.
5. Write a note on the quantitative approach to the factors influencing drug solubility.
6. Give a brief review of the gastrointestinal absorption of drugs.
Distribution Law
Very Short Answer Questions
1. Give the Nernst distribution law.
2. Give the modified equation for the Nernst distribution law.
3. Mention any two limitations of the Nernst law.
Short Answer Questions
1. Write a note on the Nernst distribution law.
2. Give the applications of the Nernst distribution law.
Long Answer Type Question
Discuss briefly the Nernst distribution law, including its limitations and applications.
State of Matter and Properties of Matter
Very Short Answer Questions
1. Define boiling and freezing.
2. Draw a graph showing the critical point.
3. State Boyle’s law.
4. Give Dalton’s law of partial pressure.
5. Mention the differences between ideal and real gases.
6. Define vapour pressure.
7. Give the units of viscosity.
8. Define relative humidity.
9. Draw a phase diagram showing a eutectic mixture.
10. Define polymorphism.
Short Answer Questions
1. Write a note on sublimation.
2. Discuss the ideal gas equation.
3. Explain the deviations from ideal gas behaviour.
4. Write a short note on aerosols.
5. How is vapour pressure affected by temperature? Explain any one method of vapour pressure measurement.
6. Write a note on liquid complexes.
7. Differentiate between crystalline and amorphous solids.
8. Write a note on crystal habit and symmetry.
9. Explain glassy states.
Long Answer Type Question
1. Discuss briefly the different gas laws.
2. Write an illustrative note on the kinetic molecular theory of gases.
3. Discuss Van der Waals equation.
4. Discuss the methods of viscosity determination.
5. Give the complete classification of crystals.
6. Give a brief review of liquid crystals.
Physicochemical Properties of Drug Molecules
Very Short Answer Questions
1. Define refractive index.
2. Give two applications of the refractive index.
3. Draw a well-labelled diagram of a polarimeter.
4. Mention the units of dipole moment.
5. Mention any two applications of the dissociation constant.
Short Answer Questions
1. How is refractive index determined?
2. Give the determination and applications of the dielectric constant.
3. Write a short note on the determination of the dipole moment.
4. How is the dissociation constant determined?
Long Answer Type Question
1. Discuss briefly about optical rotation.
2. Briefly explain the applications of dipole moment.
3. Write an illustrative note on the dissociation constant.
Surface and Interfacial Phenomena
Very Short Answer Questions
1. Define liquid interface, and give its types.
2. Mention the units of surface tension.
3. Give the applications of interfacial tension.
4. How can the spreading coefficient be enhanced?
5. Draw the HLB scale.
6. Write the Gibbs adsorption equation.
7. Draw the graph for type I and II adsorption isotherms.
8. Define contact angle and wetting.
Short Answer Questions
1. Write a note on the effect of temperature on surface tension.
2. Discuss surface free energy.
3. Explain the capillary rise method of measuring surface and interfacial tension.
4. How can the HLB value be estimated?
5. Differentiate between physical and chemical adsorption.
6. Write a note on the Freundlich adsorption isotherm.
7. Write a note on detergency.
Long Answer Type Question
1. Discuss briefly about the different methods of measuring surface and interfacial tension.
2. Give a brief review on surface active agents.
3. Write an illustrative note on solubilisation.
4. Briefly explain the different adsorption isotherms.
5. Explain solid-liquid interfaces.
Complexation and Protein Binding
Very Short Answer Questions
1. Define a complex and a complexation.
2. Give the classification of complexes.
3. What are sigma bond complexes?
4. Mention two examples of organic molecular complexes.
5. Give the applications of clathrates.
6. Draw the solubility curve of a drug in the presence of a complexing agent.
7. Enlist the factors affecting protein binding of drugs.
8. Give the principle of the dynamic dialysis method.
9. Mention any two applications of protein binding.
Short Answer Questions
1. Write a note on aromatic complexes.
2. Write about chelates.
3. What are caffeine and other drug complexes?
4. Explain monomolecular inclusion complexes.
5. Write a note on the pH titration method of analysing complexation.
6. Give a few applications of complexes in pharmacy.
7. Write a short note on the equilibrium dialysis method.
8. Explain complexation and drug action.
Long Answer Type Question
1. Write a descriptive note on metal ion complexes.
2. Discuss about inclusion complexes, along with suitable figures.
3. Give the analysis methods of complexation. And describe anyone in detail.
4. Write an illustrative note on solubility and the spectroscopic method of analysing complexation.
5. Give the kinetics of protein binding.
6. Write a descriptive note on the hermodynamic treatment of stability constants.
PH, Buffers, and Isotonic Solution
Very Short Answer Questions
1. Define pH.
2. Draw a pH scale.
3. Give the advantages of the electrometric pH determination method.
4. Write any two applications of pH.
5. What characteristics should a buffer solution possess?
6. Give the buffer equation, along with its significance.
7. Define buffer capacity.
8. What is tonicity?
9. Enlist the methods of adjusting tonicity.
Short Answer Questions
1. Write a note on Sorensen’s pH scale.
2. Give the principle and method of the colorimetric pH determination method.
3. Mention all the applications of pH.
4. What are the factors influencing the pH of a buffer solution?
5. Write a short note on buffers in the biological system.
6. Write about the standard buffer system, giving some of its examples.
7. Give the applications of buffers.
8. Explain any two methods of tonicity measurement.
Long Answer Type Question
1. Write a descriptive note on pH determination methods.
2. Discuss briefly about buffers.
3. Write an illustrative note on buffered isotonic solutions.