Physical Pharmaceutics – I
| Author’s Name | Thakur Publications Pvt. Ltd |
| Editions | Latest Edition |
| Publishers | Thakur Publicaitons Pvt. Ltd |
Physical Pharmaceutics I for B. PHARMACY PCI
| Author’s Name | Meera C. Sing |
| Editions | Latest Edition |
| Publishers | Technical Publiocation |
TPS Physical Pharmaceutics- I
| Author’s Name | Dr. (Mrs) Kanchan P. Upadhye, Dr. (Mrs) Gouri R. Dixit |
| Editions | Latest Edition |
| Publishers | VBD Publications Pvt Ltd |
Physical Pharmaceutics 1 Topic-wise Summary
Solubility of Drugs:
- Solubility expressions and mechanisms of solute–solvent interactions
- Ideal solubility parameters
- Solvation and association
- Factors influencing solubility (quantitative approach)
- Diffusion principles in biological systems
- Solubility of gases in liquids
- Solubility of liquids in liquids (binary solutions, ideal solutions)
- Raoult’s law and real solutions
- Partially miscible liquids, critical solution temperature and applications
- Distribution law, its limitations and applications
States of Matter and Properties of Matter:
- State of matter and changes in state
- Latent heats, vapour pressure, sublimation
- Critical point and eutectic mixtures
- Gases, aerosols (inhalers), relative humidity
- Liquid complexes, liquid crystals, glassy states
- Solid states: crystalline, amorphous, polymorphism
Physicochemical Properties of Drug Molecules:
- Refractive index and optical rotation
- Dielectric constant and dipole moment
- Dissociation constant
- Determination methods and applications
Surface and Interfacial Phenomena:
- Liquid interface, surface and interfacial tensions
- Surface free energy and measurement of tensions
- Spreading coefficient
- Adsorption at liquid and solid interfaces
- Surface active agents, HLB scale
- Solubilisation and detergency
Complexation and Protein Binding:
- Introduction and classification of complexation
- Applications and methods of analysis
- Protein binding
- Complexation and drug action
- Crystalline structures of complexes
- Thermodynamic treatment of stability constants
pH, Buffers and Isotonic Solutions:
- Sorensen’s pH scale
- pH determination (electrometric and calorimetric methods)
- Applications of buffers and buffer equation
- Buffer capacity
- Buffers in pharmaceutical and biological systems
- Buffered isotonic solutions