PHARMACOLOGICAL SCREENING METHODS (SEM VIII) AS PER NEW PCI SYLLABUS
| Author’s Name | BIYANI SHINDE, VITTHAL, KALE |
| Editions | Latest Edition |
| Publishers | S VIKAS AND COMPANY (PV) |
Pharmacological Screening Methods Paperback
| Author’s Name | DR NISHANT S JAIN |
| Editions | Latest Edition |
| Publishers | Nirali Prakashan |
Pharmacological Screening Methods & Toxicology: Revised & Updated Hardcover
| Author’s Name | Avanapu Srinivasa Srinivasa Rao, Namburi Bhagya Lakshmi |
| Editions | Latest Edition |
| Publishers | PharmaMed Press |
Pharmacological Screening Methods Topic-wise Summary
Laboratory Animals
- Guidelines: Study of CPCSEA and OECD guidelines for maintenance, breeding, and conduct of experiments on laboratory animals.
- Common Laboratory Animals:
- Description and applications of different species and strains of animals
- Popular transgenic and mutant animals
- Description and applications of different species and strains of animals
- Techniques:
- Collection of blood
- Common routes of drug administration in laboratory animals
- Techniques of blood collection and euthanasia
- Collection of blood
Preclinical Screening Models
a. Introduction
- Dose selection, calculation, and conversions
- Preparation of drug solutions/suspensions
- Grouping of animals and importance of sham, negative, and positive control groups
- Rationale for selection of animal species and sex for the study
b. Study of Screening Animal Models for:
- Diuretics
- Nootropics
- Anti-Parkinson’s
- Antiasthmatics
Preclinical Screening Models for CNS Activity
- Analgesic
- Antipyretic
- Anti-inflammatory
- General anesthetics
- Sedative and hypnotics
- Antipsychotic
- Antidepressant
- Antiepileptic
- Antiparkinsonism
- Alzheimer’s disease
Preclinical Screening Models for ANS Activity
- Sympathomimetics
- Sympatholytics
- Parasympathomimetics
- Parasympatholytics
- Skeletal muscle relaxants
- Drugs acting on the eye
- Local anesthetics
Preclinical Screening Models for CVS Activity
- Antihypertensives
- Diuretics
- Antiarrhythmic drugs
- Antidyslipidemic drugs
- Antiaggregatory drugs
- Coagulants and anticoagulants
Preclinical Screening Models for Other Important Drugs
- Antiulcer
- Antidiabetic
- Anticancer
- Antiasthmatics
Research Methodology and Biostatistics
- Selection of research topic
- Review of literature
- Research hypothesis and study design
- Preclinical data analysis and interpretation using:
- Student’s t-test
- One-way ANOVA
- Student’s t-test
- Graphical representation of data