Pharmaceutical Organic Chemistry 2 Important Questions are most helpful for the B.Pharm 3rd semester examination. You can also download the suggestions PDF.
Benzene and Its Derivatives
Short Answer Questions
1. Write the structure and uses of DDT.
2. What is Huckel’s rule?
3. Describe briefly the resonance in benzene.
4. Explain Friedel-Crafts reactions.
5. Why does benzene easily undergo electrophilic substitution reactions rather than nucleophilic substitution reactions?
Long Answer Questions
1. Explain electrophilic aromatic substitution reactions of benzene.
2. Explain the effect of substituents on the reactivity and orientation of monosubstituted benzene.
3. Discuss the mechanism involved in Friedel-Crafts reactions.
4. Discuss the mechanism involved in the nitration of benzene.
5. Write the structure and uses of BHC and saccharin.
Phenols, Aromatic Amines and Aromatic Acids
Short Answer Questions
1. What is the Hinsberg test?
2. Discuss the qualitative test for phenols.
3. Explain the factors responsible for the acidic character of aromatic carboxylic acids.
4. What is the diazotization reaction?
5. Why are amines basic in nature?
Long Answer Questions
1. Explain the effect of substituents on the acidic character of phenols.
2. Why do phenols undergo electrophilic substitution reactions? Give various electrophilic substitution reactions of phenols.
3. Write the structure and uses of the following organic compounds:
(a) Naphthol
(b) Resorcinol
(c) Aryl diazonium salts
(d) Cresol
4. Explain the chemical reactions of aromatic carboxylic acids.
5. Discuss the effect of substituents on the basic character of amines.
Fats and Oils
Short Answer Questions
1. What is the difference between an oil and a fat?
2. What are synthetic detergents?
3. What is the difference between hydrogenation and hydrogenolysis of oils and fats?
4. What is the main advantage of the hydrogenation of oils?
5. Write a note on the iodine value.
Long Answer Questions
1. What are lipids? Write their classification in detail.
2. What are fatty acids? Write their classification in detail.
3. Write in detail about compound lipids.
4. Write in detail about the analysis of fats and their significance in pharmacy.
5. Write in detail about the physicochemical properties of fats and oils.
Polynuclear Aromatic Hydrocarbons
Short Answer Questions
1. What are polynuclear compounds? How are they classified? Give examples of each group.
2. Discuss the constitution of naphthalene.
3. What is the modern view regarding the structure of naphthalene?
4. How will you show that naphthalene has two benzene rings fused in the ortho-position?
5. Write notes on:
(i) Orientation in the naphthalene ring system.
(ii) Electrophilic substitution reactions of naphthalene.
(iii) Bucherer reaction
(iv) Aromatic nature of naphthalene
(v) Sulphonation reaction of naphthalene
(vi) Electrophilic substitution reactions of anthracene
6. How can α and β-naphthols and naphthylamines be obtained?
7. In what respect do anthracene and phenanthrene resemble benzene? Explain why positions 9 and 10 are reactive in them.
8. Give one synthesis for each of the following:
(i) Anthracene
(ii) Naphthalene
(iii) Phenanthrene
9. Explain why the α-position of naphthalene is more reactive than the β-position.
10. What are the methods used for the synthesis of phenanthrene?
Long Answer Questions
1. What are polynuclear compounds? How are they classified? Give examples of each group.
2. How will you synthesize naphthalene? Give its chemical reactions with respect to sulphonation, chloromethylation, and Friedel-Crafts alkylation.
3. How will you prepare phenanthrene by the Haworth process? Also, write the chemical reactions and uses.
4. Write the synthesis and uses of diphenylmethane and triphenylmethane.
5. Write the method of preparation, chemical properties, and uses of anthracene.
Cycloalkanes
Short Answer Questions
1. What do you understand by the Clemmensen reduction?
2. What is the Wurtz reaction?
3. How will you prepare cycloalkanes by the Dieckmann cyclization method?
4. Write the addition reactions of cyclopropane.
5. Mention some important physical properties of cycloalkanes.
Long Answer Questions
1. Explain in detail the Baeyer strain theory and also mention its limitations.
2. Write an explanatory note on Sachse-Mohr’s theory (Theory of strainless rings).
3. Explain Coulson and Moffitt’s modification.
4. Discuss in detail the chemical reactions of cyclopropane.
5. Discuss in detail the chemical reactions of cyclobutane.