Pharmaceutical Inorganic Chemistry Important Questions are most helpful for B Pharmacy 1st semester examination. You can also download the suggestions PDF.
UNIT 1
IMPURITIES IN PHARMACEUTICAL SUBSTANCES
1) Explain the importance of inorganic chemistry in pharmacy.
2) Explain about various pharmacopoeias.
3) Write the salient features of recent editions of Indian Pharmacopoeia.
4) Briefly explain the storage conditions of drugs.
5) Describe the development of Pharmacopoeias.
6) Briefly explain the history of Indian Pharmacopoeia.
7) Write in brief the contents of the Monograph.
8) Write a short note on the monograph IP.
9) Explain the terms ‘pharmacopoeia’ and ‘monograph’. Enlist different Pharmacopoeias and
discuss salient features of the monograph.
10) Various identification tests as per IP.
11) Give the principle involved in the limit test for Iron as per IP and describe it.
12) Write in detail about raw materials as a source of impurity.
13) Enlist various sources of impurities. Discuss manufacturing hazards in detail.
14) Write in detail the limit test of Arsenic with its modifications.
15) Write specifications of the Nessler cylinder as per Pharmacopoeia.
16) Write the modifications of the limit test of Lead.
17) Give the role of – (i) Lead acetate cotton plug in limit test of Arsenic. (ii) Thioglycolic acid in
limit test of Iron.
18) Discuss the limit test of chloride for potassium permanganate.
19) Effect of impurities on properties of substances.
20) Why is the tube packed with dried cotton wool impregnated with lead acetate solution while
carrying out a limit test for arsenic?
21) Write the principle involved in the limit test for lead.
22) Enlist sources of impurities in pharmaceutical substances and explain their effects on
pharmaceutical substances.
23) Describe the limit test for iron.
24) Discuss various sources of impurities in pharmaceutical substances.
25) Explain ash value and its significance.
26) Why stagnated hydrochloric acid is used in limit tests for arsenic?
27) Discuss the limit test for sulphate.
28) Elaborate various tests for purities.
29) Explain the principle involved in the limit test for lead I.P.
30) Illustrate the sources of impurities in pharmaceutical substances.
31) Explain the types of impurities.
32) What is the effect of impurities on the quality of pharmaceuticals? Explain.
33) Explain control of impurities.
34) Describe briefly the impurities getting added during the storage of pharmacopoeial
substances.
35) Explain the importance of impurity for pharmacopoeial substances.
36) Write a brief essay on sources of impurity in pharmaceuticals.
UNIT 2
ACIDS, BASES, AND BUFFERS
1) What are the important methods of calculating isotonicity?
2) Define acids and bases. Acid as per Lewis’s theory.
3) Give Arrhenius theory.
4) What is a buffer, buffer capacity?
5) Give in detail about the buffer equation.
6) Explain the freezing point method.
7) Calculate the number of g of sodium chloride, which should be added to 120 ml of 0.5%
solution of pilocarpine hydrochloride to make it isotonic.
8) Calculate the number of g of sodium chloride needed to render 30 ml of physostigmine
salicylate solution isotonic.
MAJOR EXTRA AND INTRACELLULAR ELECTROLYTES
1) Define the following terms: Molarity, Equivalent weight, Osmolality, Molality, Osmolarity,
Milliequivalent.
2) Give the composition of intra and extracellular electrolytes.
3) What are intra and extracellular ions? Give their important physiological roles.
4) Comment on electrolyte replacement therapy.
5) Explain the role of intra and extracellular ions in maintaining physiological balance.
6) What are electrolytes? Enlist major intra and extracellular electrolytes.
7) Discuss the role of sodium and potassium as an important electrolyte.
8) Discuss various electrolytes used in sodium, potassium, and calcium replacement.
9) What is metabolic acidosis and alkalosis?
10) Comment on functions of Na+ and K+ ions in the body.
11) How acid-base balance of the body is maintained?
12) Enlist the electrolytes used in physiological acid-base balance.
13) Write a note on oral rehydration salt (ORS).
14) Explain the role of electrolytes in acid-base therapy.
15) Explain the term milliequivalent. Calculate the number of mEq of potassium chloride in one
litre of a 0.48% w/v solution.
16) Enlist official sodium chloride formulations used in electrolyte replacement therapy.
17) Explain the physiological role of chloride and bicarbonate.
18) How electrolyte combinations are used as replacement therapy? Explain.
19) What do you understand by electrolyte replacement therapy?
20) Write a note on the following: (a) Physiological acid-base balance (b) Electrolyte used as
acid-base therapy (c) Electrolyte combination therapy (d) Electrolyte replacement therapy (e)
Pharmaceutical application of electrolytes (f) Physiological role of Na+ and K+ ions as
electrolytes (g) Electrolyte replenishes (h) ORS.
DENTAL PRODUCTS
1) Write notes on – (a) Anti-caries agents. (b) Calcium compounds as dentifrices. (c) Preparation,
properties, uses and assay of sodium fluoride. (d) Role of fluoride as an anticaries agent.
2) Discuss the mechanism of action of anti-caries agents.
3) Explain the role of fluoride and phosphate in tooth decay.
4) Explain the role of fluorides in tooth decay.
5) Write a note on: dentifrices and desensitizing agents.
6) Write about dentifrices.
7) Comment on zinc oxide eugenol cement (ZOE).
UNIT 3
GASTROINTESTINAL AGENTS
1) Justify the role of acidifying agents in medical treatment as well as physiology.
2) Enumerate the role of gastric acid in the body.
3) Write a short note on the estimation of HCl (IP).
ANTACIDS
1) What are antacids? Classify them and discuss the characteristics of an ideal antacid.
2) What are combination antacids and discuss some important combinations?
3) What is the role of simethicone in antacid preparations?
4) Write a note on any class of inorganic antacids: (i) Aluminium, (ii) Magnesium, (iii)
Sodium.
5) Give a brief monograph of any one of the following important inorganic GIT agents: (i)
Aluminium hydroxide gel (ii) Magnesium oxide (iii) Calcium carbonate (iv) Magnesium
carbonate (v) Magnesium hydroxide (vi) Magnesium trisilicate (vii) Sodium bicarbonate.
CATHARTICS
1) Discuss any one of the following saline cathartics in detail: (i) Sodium phosphate, (ii) Sodium
potassium tartrate, (iii) Magnesium carbonate, (iv) Magnesium sulphate.
2) Discuss saline cathartics with respect to their definition, role, and mechanism of action.
ANTIMICROBIALS
1) Define the terms: (a) Bacteriostatic, (b) Bactericidal, (c) Disinfectants, (d) Antiseptics, (e)
Germicides.
2) Write notes on: Boric acid, Iodine solution, Hydrogen peroxide, Potassium permanganate,
Chlorinated lime.
3) Write a note on iodine preparations as topical agents.
4) Describe with principle and reaction involved in hydrogen peroxide assay.
5) Comment on the assay of potassium permanganate.
6) Discuss different mechanisms of action for antimicrobial agents with suitable figures.
UNIT 4
MISCELLANEOUS COMPOUNDS (EXPECTORANTS, EMETICS, HAEMATINICS,
POISON AND ANTIDOTE, ASTRINGENTS)
1) Give a classification of antidotes on the basis of their mechanism of action with examples.
Explain the mechanism of action of sodium nitrite and sodium thiosulphate intravenous infusion
in cyanide poisoning.
2) Discuss sodium thiosulphate as an antidote.
3) Describe the method of preparation, uses and assay of compounds used in cyanide poisoning.
4) What are expectorants and emetics? Give their mechanism of action. (a) Ammonium chloride
(b) KI
5) Explain the reactions involved in the assay of KI.
6) What are expectorants? Explain the assay of ammonium chloride.
7) Write a note on expectorants.
8) Describe in detail the following inorganic compounds (any 2): (a) KI, (b) Na2S2O3, (c)
NH4Cl.
9) Describe the principle behind using ammonium chloride as an expectorant. Also, mention the
reaction involved in its principle and describe the method of assay.
10) What are antidotes? Classify them with examples. Write a note on cyanide poisoning.
11) Define antidotes and explain their mechanism of action.
12) Discuss haematinics, particularly ferrous sulphate and ferrous gluconate.
13) What is poisoning? Explain various types.
UNIT 5
RADIOPHARMACEUTICALS
1) Define radioactivity. Describe the methods available for the measurement of radioactivity.
2) Describe the properties of alpha, beta, and gamma radiations.
3) Describe radioisotopes with examples.
4) Explain radiopharmaceuticals with examples.
5) What are the storage conditions and precautions required for radioactive materials?
6) Elaborate pharmaceutical applications of radioactive substances.
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