B.Pharm Pharmaceutical Organic Chemistry 2 Notes

PHARMACEUTICAL ORGANIC CHEMISTRY 2 UNIT-WISE NOTES – BP301T

Unit – 1

• Benzene and its derivatives:
• A. Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
• B. Reactions of benzene – nitration, sulphonation, halogenation reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
• C. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
• D. Structure and uses of DDT, Saccharin, BHC and Chloramine

Unit – 2

• Phenols* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
• Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
• Aromatic Acids* –Acidity, effect of substituents on acidity and important reactions of benzoic acid.

Unit – 3

• Fats and Oils:
• a. Fatty acids – reactions.
• b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
• c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

Unit – 4

• Polynuclear hydrocarbons:
• a. Synthesis, reactions
• b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

Unit – 5

• Cyclo alkanes:
• Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only.