Pharmacological Screening Methods B.Pharm 8th Semester Books

PHARMACOLOGICAL SCREENING METHODS (SEM VIII) AS PER NEW PCI SYLLABUS

Author’s Name	BIYANI SHINDE, VITTHAL, KALE
Editions	Latest Edition
Publishers	S VIKAS AND COMPANY (PV)

Pharmacological Screening Methods Paperback

Author’s Name	DR NISHANT S JAIN
Editions	Latest Edition
Publishers	Nirali Prakashan

Pharmacological Screening Methods & Toxicology: Revised & Updated Hardcover

Author’s Name	Avanapu Srinivasa Srinivasa Rao, Namburi Bhagya Lakshmi
Editions	Latest Edition
Publishers	PharmaMed Press

Pharmacological Screening Methods Topic-wise Summary

Laboratory Animals

• Guidelines: Study of CPCSEA and OECD guidelines for maintenance, breeding, and conduct of experiments on laboratory animals.
  
• Common Laboratory Animals:
  
  • Description and applications of different species and strains of animals
    
  • Popular transgenic and mutant animals
    
• Techniques:
  
  • Collection of blood
    
  • Common routes of drug administration in laboratory animals
    
  • Techniques of blood collection and euthanasia

Preclinical Screening Models

a. Introduction

• Dose selection, calculation, and conversions
  
• Preparation of drug solutions/suspensions
  
• Grouping of animals and importance of sham, negative, and positive control groups
  
• Rationale for selection of animal species and sex for the study

b. Study of Screening Animal Models for:

• Diuretics
  
• Nootropics
  
• Anti-Parkinson’s
  
• Antiasthmatics

Preclinical Screening Models for CNS Activity

• Analgesic
  
• Antipyretic
  
• Anti-inflammatory
  
• General anesthetics
  
• Sedative and hypnotics
  
• Antipsychotic
  
• Antidepressant
  
• Antiepileptic
  
• Antiparkinsonism
  
• Alzheimer’s disease

Preclinical Screening Models for ANS Activity

• Sympathomimetics
  
• Sympatholytics
  
• Parasympathomimetics
  
• Parasympatholytics
  
• Skeletal muscle relaxants
  
• Drugs acting on the eye
  
• Local anesthetics

Preclinical Screening Models for CVS Activity

• Antihypertensives
  
• Diuretics
  
• Antiarrhythmic drugs
  
• Antidyslipidemic drugs
  
• Antiaggregatory drugs
  
• Coagulants and anticoagulants

Preclinical Screening Models for Other Important Drugs

• Antiulcer
  
• Antidiabetic
  
• Anticancer
  
• Antiasthmatics

Research Methodology and Biostatistics

• Selection of research topic
  
• Review of literature
  
• Research hypothesis and study design
  
• Preclinical data analysis and interpretation using:
  
  • Student’s t-test
    
  • One-way ANOVA
    
• Graphical representation of data