Biopharmaceutics and Pharmacokinetics B.Pharm 6th Semester Books

Biopharmaceutics & Pharmacokinetics Book for B.Pharm 6th Semester

Author’s Name	Dr. Sunil Kumar Dr. N. Deattu, Dr. (Prof.) N.B. Santha Sheela
Editions	Latest Edition
Publishers	Thakur Publication Pvt Ltd

A Textbook of Biopharmaceutics and Pharmacokinetics, B.Pharmacy VI-Semester

Author’s Name	Dr.Shaik Harun Rasheed
Editions	Latest Edition
Publishers	SIA Publishers & Distributors Pvt Ltd

BIOPHARMACEUTICS AND PHARMACOKINETICS (SEM VI) Textbook

Author’s Name	ATUL AKSHAY, RAQEEB
Editions	Latest Edition
Publishers	S VIKAS AND COMPANY (PV)

Biopharmacutics and Pharmacokinetics – A Treatise Paperback

Author’s Name	Brahmankar Jaiswal
Editions	Latest Edition
Publishers	Vallabha prakashan

Biopharmaceutics and Pharmacokinetics Topic-wise Summary

Introduction to Biopharmaceutics

1. Absorption
   
   • Mechanisms of drug absorption through GIT
     
   • Factors influencing drug absorption through GIT
     
   • Absorption of drugs from non-per-oral extravascular routes
     
2. Distribution
   
   • Tissue permeability of drugs
     
   • Binding of drugs
     
   • Apparent volume of drug distribution
     
   • Plasma and tissue protein binding of drugs
     
   • Factors affecting protein-drug binding
     
   • Kinetics of protein binding
     
   • Clinical significance of protein binding of drugs

Elimination

1. Drug metabolism and basic understanding of metabolic pathways
   
2. Renal excretion of drugs
   
   • Factors affecting renal excretion of drugs
     
   • Renal clearance
     
3. Non-renal routes of drug excretion
   

Bioavailability and Bioequivalence

1. Definitions and objectives of bioavailability
   
2. Absolute and relative bioavailability
   
3. Measurement of bioavailability
   
4. In-vitro drug dissolution models
   
5. In-vitro–in-vivo correlations
   
6. Bioequivalence studies
   
7. Methods to enhance the dissolution rates and bioavailability of poorly soluble drugs
   

Pharmacokinetics

1. Definition and introduction to pharmacokinetics
   
2. Models of pharmacokinetics
   
   • Compartment models
     
   • Non-compartment models
     
   • Physiological models
     
   • One-compartment open model:
     a. Intravenous injection (Bolus)
     b. Intravenous infusion
     c. Extravascular administration
     
3. Pharmacokinetic parameters
   
   • KE (Elimination rate constant)
     
   • t1/2 (Half-life)
     
   • Vd (Volume of distribution)
     
   • AUC (Area under curve)
     
   • Ka (Absorption rate constant)
     
   • Clt (Total clearance)
     
   • CLR (Renal clearance)
     
4. Definition, methods of estimation, significance, and clinical application of parameters

Multicompartment Models

1. Two-compartment open model
   
2. IV bolus kinetics
   
3. Kinetics of multiple dosing
   
4. Steady-state drug levels
   Calculation of loading and maintenance doses and their clinical significance
   

Nonlinear Pharmacokinetics

1. Introduction
2. 
   
3. Factors causing non-linearity
   
4. Michaelis-Menten method of estimating parameters
   
5. Explanation with examples of drugs