Text Book Biochemistry
| Author’s Name | Rahul B. Lovhare, Dr. Sunil P. Pawar |
| Editions | Latest Editions |
| Publishers | GLOBAL EDUCATION LIMITED |
Biochemistry: First Year B. Pharm. / SEM-2
| Author’s Name | Dr. Mrs. Padmaja H. Agarkar, Dr. Yogesh Kulkarni |
| Editions | First Edition |
| Publishers | Nirali Prakashan |
Biochemistry Book for B.Pharm 2nd Semester
| Author’s Name | Dr. Upma N. Trivedi & Dr. Anuradha Singh Dr. G. Murugananthan |
| Editions | Latest Editions |
| Publishers | Thakur Publication Pvt Ltd |
Biochemistry Topic-wise Summary
Biomolecules
- Introduction, classification, chemical nature, and biological role of carbohydrates, lipids, nucleic acids, amino acids, and proteins.
Bioenergetics
- Concept of free energy, endergonic and exergonic reactions.
- Relationship between free energy, enthalpy, and entropy; redox potential.
- Energy-rich compounds: classification and biological significance of ATP and cyclic AMP.
Carbohydrate Metabolism
- Glycolysis – pathway, energetics, and significance.
- Citric acid cycle – pathway, energetics, and significance.
- HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency.
- Glycogen metabolism – pathways and glycogen storage diseases (GSD).
- Gluconeogenesis – pathway and significance.
- Hormonal regulation of blood glucose level and diabetes mellitus.
Biological Oxidation
- Electron transport chain (ETC) and its mechanism.
- Oxidative phosphorylation and substrate phosphorylation – mechanisms.
- Inhibitors of ETC and oxidative phosphorylation/uncouplers.
Lipid Metabolism
- β-oxidation of saturated fatty acid (palmitic acid).
- Formation and utilization of ketone bodies; ketoacidosis.
- De novo synthesis of fatty acids (palmitic acid).
- Biological significance of cholesterol and conversion of cholesterol into bile acids, steroid hormones, and vitamin D.
- Disorders of lipid metabolism: hypercholesterolemia, atherosclerosis, fatty liver, and obesity.
Amino Acid Metabolism
- General reactions of amino acid metabolism: transamination, deamination, decarboxylation, urea cycle and its disorders.
- Catabolism of phenylalanine and tyrosine and their metabolic disorders (phenylketonuria, albinism, alkaptonuria, tyrosinemia).
- Synthesis and significance of biological substances: 5-HT, melatonin, dopamine, noradrenaline, adrenaline.
- Catabolism of heme; hyperbilirubinemia and jaundice.
Nucleic Acid Metabolism and Genetic Information Transfer
- Biosynthesis of purine and pyrimidine nucleotides.
- Catabolism of purine nucleotides; hyperuricemia and gout disease.
- Organization of the mammalian genome.
- Structure of DNA and RNA and their functions.
- DNA replication (semi-conservative model).
- Transcription or RNA synthesis.
- Genetic code, translation or protein synthesis, and inhibitors.
Enzymes
- Introduction, properties, nomenclature, and IUB classification of enzymes.
- Enzyme kinetics (Michaelis plot, Lineweaver–Burk plot).
- Enzyme inhibitors with examples.
- Regulation of enzymes: enzyme induction and repression, allosteric enzyme regulation.
- Therapeutic and diagnostic applications of enzymes and isoenzymes.
- Coenzymes – structure and biochemical functions.